Oil of Oregano is a powerful plant extract with highly effective antimicrobial properties, as well as important antioxidant and anti-inflammatory activities.
The principal phenolic compounds in oregano—carvacrol [2-methyl-5-(1- methyl ethyl) phenol] and thymol (2-isopropyl-5methylphenol)—are well known for their individual antibacterial properties, but when synergistically functioning alongside the other biologically active monoterpenes of oregano,
these compounds convey potent antimicrobial actions. They have both been shown to be biocidal against numerous Gram-positive and Gram-negative
bacteria including Listeria, Salmonella, Pseudomonas, H. pylori, and E. coli in the jejunum, ileum, and colon. In vitro studies showed oil of oregano to be highly effective in dismantling and attenuating the growth of biofilms produced by various species of Staphylococcus, Streptococcus, E. coli, and
Salmonella.11-15 The researchers proposed that the hydrophobic properties of carvacrol and thymol enabled them to interact with the lipid bilayer of bacterial cell membranes, “causing loss of integrity and leakage of cellular material such as ions, ATP and nucleic acids.”
In the presence of these
compounds, bacterial cells grew as looser colonies and the amount of biofilm
was reduced in direct proportion to the dose of oregano extracts.
The activity of oil of oregano at the subcellular level is confirmed by studies that demonstrated disruption of the cell membranes and intracellular structures, damage of cytoplasmic vacuoles, disturbance of membrane embedded proteins, lipids, RNA synthesis, ATPase activity, and an imbalance of intracellular osmotic pressure as cytoplasmic contents have leaked in Staph and Pseudomonas organisms exposed to oregano oil.
Recommended Use: Take 1 softgel per day with a meal or as directed by your health-care practitioner.
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