
Q&A: Blood Clots & HRT, IUD, Loose Skin Post Weight Loss, Ovarian Failure, Amenorrhea, and MORE!
It's time for another Q&A episode. I'm answering listener questions about bioidentical HRT, the risks associated with oral estrogens, and so much more. Additionally, we'll discuss the Mirena IUD's impact on hormone levels, address concerns about loose skin after weight loss, and weigh the pros and cons of different HRT methods for women experiencing premature ovarian deficiency. I'll also provide my insight on the role of diet, thyroid function, and even probiotics in managing HRT side effects.
In this episode we discuss:
- Why some women experience quick benefits from bioidentical HRT, while others need more adjustments.
- The risks associated with oral estrogens, especially for those with the factor V genetic variant.
- Why transdermal estrogen is a safer alternative to oral forms.
- How the Mirena IUD affects hormone levels and natural progesterone production.
- The long-term health implications of synthetic progestins, plus strategies for integrating natural bioidentical progesterone.
- Concerns about loose skin after weight loss, along with solutions like muscle-building exercises.
- The pros and cons of different HRT methods for women with premature ovarian deficiency.
- Why achieving therapeutic hormone levels is crucial for protecting against health risks.
- How to manage weight gain concerns related to HRT, including adjusting dosages and supporting detoxification pathways.
- The role of diet, thyroid function, and probiotics in managing HRT side effects.
- Why a balanced intake of carbohydrates is important for metabolic health.
- The potential influence of COVID-19 and its vaccine on menstrual health.
- The necessity and effectiveness of probiotics for gut health.
- Strategies for improving sleep and managing HRT side effects like headaches and hair growth.
- How to identify the culprit hormone causing weight gain and swelling by adjusting doses.
- The efficacy of calcium D-glucarate and N-acetylcysteine in managing estrogen-related weight gain.
- The importance of monitoring hormone levels despite a doctor's refusal to conduct lab tests.
- How tirzepatide affects weight loss beyond appetite suppression.
Download in iTunes or on your favorite podcast platform.

Find Karen Martel on Apply Podcast
Karen Martel is a Certified Hormone Specialist and Transformational Nutrition Coach dedicated to empowering women through their health journeys.
As the host of the popular podcast The Hormone Solution, Karen tackles the complexities of hormonal health, weight loss resistance, and the challenges that come with perimenopause and menopause.
Her mission is to disrupt outdated narratives surrounding women's health, providing reliable information and practical solutions that help women reclaim their vitality. With personal experience overcoming her own health struggles, Karen offers insights into hormone optimization and sustainable weight management strategies.
Join her as she engages in enlightening conversations with experts and shares actionable advice, all aimed at helping women navigate their unique hormonal landscapes with confidence and clarity. Tune in to discover how to embrace life's stages while enhancing overall well-being.