
Quick Hits: The Power of Your Genes and What They Can Tell You About Your Health, Ability to Lose Weight, Detox and More!
Welcome to Quick Hits: Blasts from The Past. Join Karen as she explores her podcast archives, offering you short, impactful excerpts from standout episodes. In just 15 minutes, you'll experience the essence of past conversations, packed with valuable insights and memorable moments from our guests. If you want to dive deeper, you'll find links to the full episodes in the show notes below. What if your weight loss struggles aren’t about discipline or calories—but about how your genes process inflammation, carbs, and toxins?
In this episode, I’m joined by functional health expert and former malpractice attorney Sam, who breaks down how your genetic pathways affect everything from weight loss resistance to detox capacity, hormone metabolism, and food sensitivities.
Forget obsessing over one red MTHFR gene—this episode will teach you how to see the whole genetic picture, so you can personalize your diet, detox, and supplement strategy for real results.
What We Cover:
- Why some women gain more fat the more they exercise (yep, it’s genetic!)
- The Muffin Test: A surprising clue that your inflammation genes are out of balance
- Inflammation, water retention, and the hidden reason for overnight weight gain
- The concept of hormonal toxic fat and how poor detoxification can trap weight
- The myth of “willpower” and why toxic load may be sabotaging your best efforts
- How mineral deficiencies + heavy metals mess with your enzyme function
- What your copy number genes say about your carb tolerance and ideal diet
- Why your fat cells are like toxic closets—and how to open them safely
Why It Matters:
Your genes are not a death sentence—they're a user manual. Whether you struggle with weight loss, detox overload, mood swings, or midlife mystery symptoms, understanding your genetic code is the first step to healing.
This episode will empower you to stop blaming your body—and start working with it instead.
Visit Dr. Sam Shay's website here.
Download in iTunes or on your favorite podcast platform.

Find Karen Martel on Apply Podcast
Karen Martel is a Certified Hormone Specialist and Transformational Nutrition Coach dedicated to empowering women through their health journeys.
As the host of the popular podcast The Hormone Solution, Karen tackles the complexities of hormonal health, weight loss resistance, and the challenges that come with perimenopause and menopause.
Her mission is to disrupt outdated narratives surrounding women's health, providing reliable information and practical solutions that help women reclaim their vitality. With personal experience overcoming her own health struggles, Karen offers insights into hormone optimization and sustainable weight management strategies.
Join her as she engages in enlightening conversations with experts and shares actionable advice, all aimed at helping women navigate their unique hormonal landscapes with confidence and clarity. Tune in to discover how to embrace life's stages while enhancing overall well-being.