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The Women's Hormone Masterclass with Dr. Kyle Gillett: A Deep Dive Into Testosterone, Dutasteride, SHBG, & Menopause Weight Gain

kyle Gillet



In this episode we discuss:

  • How androgens such as testosterone, DHEA, and dihydrotestosterone affect women's well-being.
  • Why sex hormone binding globulin (SHBG) is critical for hormone dynamics and stability.
  • Understanding the impact of thyroid binding globulin and cortisol binding globulin on hormone balance.
  • How hormone replacement therapy (HRT) influences women's bodies, especially regarding androgens.
  • Managing testosterone replacement therapy to avoid virilization symptoms like facial hair and voice changes.
  • The role of DHT blockers in managing androgen-related conditions.
  • How SHBG can be harnessed for overall hormone stability and health benefits.
  • Challenges of menopausal weight gain and how hormonal changes affect body composition.
  • Why integrating proper lifestyle habits is essential alongside GLP-1 medications for effective weight loss.
  • How to maintain lean body mass through hormone therapy and lifestyle changes.
  • How oral contraceptives and other synthetic hormones impact SHBG levels and overall hormone balance.
  • The significance of SHBG levels for individuals on hormone replacement therapy or contraceptives.
  • Exploring different forms of testosterone administration, including subcutaneous and intramuscular injections.
  • How estrogen and progesterone influence testosterone levels through negative feedback inhibition.
  • How poor sleep quality and hormonal changes contribute to menopausal weight gain.
  • The paradoxical effects of hormone replacement therapy on body composition and fat gain.
  • Why high SHBG must be paired with adequate hormone levels to avoid feeling unwell.
  • Discussing the challenges faced when SHBG levels are artificially high due to medication.


Download in iTunes or on your favorite podcast platforms.

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