Topical Estriol + Estradiol for Skin Support

Bioidentical creams containing estriol and estradiol may be incorporated into a skincare routine to support the skin’s appearance as it matures. These ingredients have been researched for their potential to help maintain hydration, elasticity, and skin texture, all of which may shift with age.

When applied topically, estrogens have been studied for their influence on collagen and elastin, which contribute to skin firmness and the appearance of fine lines. This cream is formulated for precise, low-dose application, making it a thoughtful addition to a broader personal care or wellness regimen.

Many users explore bioidentical creams as part of their midlife routines to support their overall sense of balance and well-being—always in consultation with a trusted healthcare provider.

For best results, use under the guidance of a qualified practitioner to ensure appropriate usage based on your individual needs.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research on estriol and estradiol topical face creams has shown promising results for improving skin health and reducing signs of aging. Studies have investigated the effects of these creams on various skin parameters, including collagen production, skin thickness, and wrinkle reduction.

Estriol Cream (0.3%)

A clinical study assessed the efficacy of a 0.3% estriol topical facial cream compared to a 0.01% estradiol cream and a placebo control over 12 weeks[1]. The study evaluated various skin health parameters, including fine lines, wrinkles, skin tone, radiance, roughness, firmness, pores, hydration, and elasticity.

Estradiol Cream (0.01%)

Several studies have examined the effects of 0.01% estradiol cream on skin:

1. Collagen production: A study on postmenopausal women using systemic estrogen therapy found that additional topical 0.01% estrogen treatment for 16 weeks significantly increased the amount of skin collagen (p<0.001)[2].

2. Skin thickness: The same study reported enhanced epithelial and dermal thickness after topical estrogen therapy (p<0.01)[2].

3. Photoaged skin: A two-week treatment with 0.2% estradiol cream twice daily on photodamaged facial skin did not show significant changes in collagen production, despite similar estrogen receptor expression in aged and photoaged skin[3].

4. Sun-protected skin: In contrast, the same study found that estradiol treatment stimulated collagen production in sun-protected hip skin of postmenopausal women and, to a lesser extent, in age-matched men[3].

Long-term Effects

A six-month study comparing 0.01% estradiol and 0.3% estriol compounds in preclimacteric women with skin aging symptoms reported:

1. Improved elasticity and firmness of the skin
2. Decreased wrinkle depth and pore sizes by 61 to 100% in both groups
3. Increased skin moisture
4. Significant increases in Type III collagen and collagen fiber numbers[4]

These studies suggest that topical estrogen creams, particularly in sun-protected areas, may have beneficial effects on aging skin. However, more research is needed to fully understand their efficacy and long-term safety.

Citations:
[1] https://assets.ctfassets.net/md0kv0ejg0xf/4gaULAkbHbgNZtNMOgg1PI/91329de08abacf438fb83d99e756ee99/Alloy_M4_Report_063024.pdf
[2] https://pubmed.ncbi.nlm.nih.gov/16797821/
[3] https://jamanetwork.com/journals/jamadermatology/fullarticle/420008
[4] https://pubmed.ncbi.nlm.nih.gov/8876303/

Always consult with your healthcare provider before using products containing hormones.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Q1: How can this product support me during menopause?

A:
Midlife transitions can bring a range of physical and emotional changes. Estro2 Rejuvenate Cream is formulated with bioidentical estradiol and estriol, ingredients studied for their potential to support the skin and contribute to a sense of well-being. Many women choose to include topical estrogen in their wellness routines to complement healthy lifestyle practices and help them feel more balanced during this phase.

Always consult with a qualified healthcare provider before using hormone-based products, especially during perimenopause.

Q2: Can this cream improve the appearance of my skin as I age?

A:
Topical estrogens like estriol and estradiol have been studied for their potential benefits on mature skin, including hydration, elasticity, and collagen support. Some research suggests they may contribute to improvements in skin texture, fine lines, and overall tone. While individual results may vary, Estro2 Rejuvenate is formulated with these ingredients to support your skincare goals during midlife.

Q3: Will applying this to my face affect my hormone levels?

A:
Yes, applying topical estrogen to any area of the skin can be absorbed systemically. Even small doses may influence overall hormone levels, depending on factors such as dosage, skin thickness, and frequency of use.

We recommend consulting a healthcare provider to determine appropriate use for your individual situation, especially if you are still menstruating or cycling.

Q4: Why choose Estro2 Rejuvenate?

A:
Estro2 Rejuvenate offers a thoughtful blend of USP-grade bioidentical hormones in a clean, professional-strength base. It’s crafted for precision dosing, suitable for both facial and body application. With quality ingredients and a wellness-forward formulation, it’s designed for those seeking to support their skin and well-being as part of a broader self-care routine.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.