Topical estriol and estradiol may be used as part of a skincare routine to support skin health. These bioidentical creams are believed to have potential benefits for the skin, helping to maintain hydration and elasticity, which can be affected by age-related changes in collagen and elastin production. Estrogens may assist with the appearance of fine lines and wrinkles, and can support the skin's overall resilience and firmness.

This bioidentical hormone cream is designed to help address hormonal balance during menopause, which may impact mood, energy levels, and skin health. It is formulated with precise dosing for topical application and can be used as part of a broader skincare regimen.

Research on estriol and estradiol topical face creams has shown promising results for improving skin health and reducing signs of aging. Studies have investigated the effects of these creams on various skin parameters, including collagen production, skin thickness, and wrinkle reduction.

Estriol Cream (0.3%)

A clinical study assessed the efficacy of a 0.3% estriol topical facial cream compared to a 0.01% estradiol cream and a placebo control over 12 weeks[1]. The study evaluated various skin health parameters, including fine lines, wrinkles, skin tone, radiance, roughness, firmness, pores, hydration, and elasticity.

Estradiol Cream (0.01%)

Several studies have examined the effects of 0.01% estradiol cream on skin:

1. Collagen production: A study on postmenopausal women using systemic estrogen therapy found that additional topical 0.01% estrogen treatment for 16 weeks significantly increased the amount of skin collagen (p<0.001)[2].

2. Skin thickness: The same study reported enhanced epithelial and dermal thickness after topical estrogen therapy (p<0.01)[2].

3. Photoaged skin: A two-week treatment with 0.2% estradiol cream twice daily on photodamaged facial skin did not show significant changes in collagen production, despite similar estrogen receptor expression in aged and photoaged skin[3].

4. Sun-protected skin: In contrast, the same study found that estradiol treatment stimulated collagen production in sun-protected hip skin of postmenopausal women and, to a lesser extent, in age-matched men[3].

Long-term Effects

A six-month study comparing 0.01% estradiol and 0.3% estriol compounds in preclimacteric women with skin aging symptoms reported:

1. Improved elasticity and firmness of the skin
2. Decreased wrinkle depth and pore sizes by 61 to 100% in both groups
3. Increased skin moisture
4. Significant increases in Type III collagen and collagen fiber numbers[4]

These studies suggest that topical estrogen creams, particularly in sun-protected areas, may have beneficial effects on aging skin. However, more research is needed to fully understand their efficacy and long-term safety.

Citations:
[1] https://assets.ctfassets.net/md0kv0ejg0xf/4gaULAkbHbgNZtNMOgg1PI/91329de08abacf438fb83d99e756ee99/Alloy_M4_Report_063024.pdf
[2] https://pubmed.ncbi.nlm.nih.gov/16797821/
[3] https://jamanetwork.com/journals/jamadermatology/fullarticle/420008
[4] https://pubmed.ncbi.nlm.nih.gov/8876303/

Always consult with your healthcare provider before using products containing hormones.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Q1: How can this product help me feel like myself again during menopause?

A: Menopause can feel overwhelming, but Estro2 Rejuvenate Cream is designed to restore balance, helping you manage mood swings, boost energy, and reclaim your confidence. Its bioidentical hormones work gently to bring relief from hot flashes, improve sleep, and support vaginal health—because you deserve to feel vibrant and in control.

Q2: Will this cream improve my skin’s appearance as I age?

A: Estro2 is designed to support hormonal balance during menopause, which can have an impact on skin health. This bioidentical hormone cream may help to hydrate the skin and assist in maintaining its natural elasticity. Research has suggested that topical estrogens may have potential benefits for skin health, such as improving the appearance of fine lines, decreasing pore size, and supporting collagen production. However, individual results may vary, and it is important to remember that this product is not intended to diagnose, treat, cure, or prevent any disease. For personalized advice, we recommend consulting with your healthcare provider before use.

Q3: Will this raise my systemic levels if I only apply to my face?

Yes, Estro2 estrogen cream can raise systemic estrogen levels. While some research suggests that applying a small amount to the face may not significantly affect overall hormone levels, we cannot guarantee that it won't raise systemic levels. It is advised to consult with your healthcare provider before using this product to ensure it is appropriate for your individual health needs. Caution is advised if you are still cycling, and it is not recommended to use the 4-pump dose of this product systemically on the body while still menstruating.

Q4: Why should I choose Estro2 over other options?

A: Unlike other products, Estro2 combines precision-dosed bioidentical hormones with a clean, professional-strength formula. It’s crafted with care to meet your unique needs—whether you’re managing menopausal changes or looking to nurture your skin. With every application, you’re choosing a product designed to help you thrive, not just survive.